University of Colorado

2022

• Derk, J, Como, CN, Jones, HE, Joyce, LR, Bonney, S, O'Rourke, R, Pawlikowski, B, Doran, KS, Siegenthaler JA (2022) 'Formation and function of the meninges arachnoid barrier around the developing brain' BioRxiv link to article
  
• Como, CN, Cervantes, C, Pawlikowski, B, Siegenthaler, JA (2022) 'Retinoic acid signaling in mouse retina endothelial cells is required for early angiogenic growth' BioRxiv link to article
  
• Jones, HE, Abrams, K, Siegenthaler, JA (2022) 'Techniques for visualizing fibroblast-vessel interactions in the developing and adult CNS' Neurophotonics, 9(2), 021911. link to article SPIE highlight article
  

2021

• Como, CN, Jones, HE, Siegenthaler, JA (2021) 'Not just a 'drain': venules sprout brain capillaries' Trends in Neuroscience Nov;44(11):849-851. link to article
• Dorrier, CE, Jones, HE, Pintarić, L, Siegenthaler, JA* and Daneman, R* (2021) "Emerging roles for CNS fibroblasts in health, injury and disease." Nature Review Neuroscience October 20, 2021. link to article *co-corresponding authors
• Derk, J, Jones, HE, Como, C, Pawlikowski, B, Siegenthaler, JA (2021) "Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease." Frontiers in Cellular Neuroscience July 1, 2021. link to article

2020

• DeSisto, J, O'Rourke, R, Jones, HE, Pawlikowski, B, Malek, A, Bonney, S, Guimiot, F, Jones, KL, Siegenthaler, JA (2020) "Single-cell transcriptomic analyses of the developing meninges reveal meningeal fibroblast diversity and function." Developmental Cell July 6; 54(1):43-59. link to article  **Blog post on article from 10x Genomics

2019

• Bonney, S, Seitz, S, Ryan, CA, Jones, KL, Clarke, P, Tyler, KL, Siegenthaler, JA  (2019) “IFNγ alters junctional integrity via Rho-kinase resulting in BBB leakage in experimental viral encephalitis.” mBio Aug 6;10(4). pii: e01675-19 PubMed **Press Release
• DeSisto, J, O'Rourke, R, Bonney, S, Jones, HE, Guimiot, F, Jones, KL, Siegenthaler, JA (2019) "A cellular atlas of the developing meninges reveals meningeal fibroblast diversity and function." bioRxiv link to article
• Pawlikowski, B, Wragge, J, Siegenthaler, JA (2019) "Retinoic acid signaling in vascular development." Genesis doi: 10.1002/dvg.23287 PubMed

2018

• Bonney S, Dennison, BJC, Wendlandt, M, Siegenthaler, JA (2018) "Retinoic acid regulates endothelial β-catenin expression and pericyte numbers in the developing brain vasculature." Frontiers in Cellular Neuroscience PubMed
• Mishra, S, Kelly, KK, Rumian, NL, Siegenthaler, JA (2018) "Retinoic acid is required for neural stem and progenitor cell proliferation in the adult hippocampus." Stem Cell Reports DOI: https://doi.org/10.1016/j.stemcr.2018.04.024. PubMed  (Article selected for preview in Stem Cell Reports) 

2017    

• Bonney, S and Siegenthaler JA (2017) “Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties.” eNEURO May 26;4(3) DOI: 10.1523/ENEURO.0378-16.2017. PubMed
• Wilde, JJ, Siegenthaler JA, Dent, SY, Niswander, L (2017) ”Diencephalic size is restricted by a novel interplay between GCN5 acetyltransferase activity and retinoic acid signaling.” Journal of Neuroscience Mar 8;37(10):2565-2579. PubMed

2016

• Mishra, S, Choe, Y, Pleasure, SJ, Siegenthaler JA (2016) “Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGFA pathways downstream of retinoic acid from the meninges.” Developmental Biology doi: 10.1016/j.ydbio.2016.09.019. PubMed
• Bonney*, S, Harrison-Uy*, S, Mishra, S, MacPherson, A, Choe, Y, Li, D, Jaminet, SC, Fruttiger, M, Pleasure, SJ and Siegenthaler, JA (2016) “Diverse functions of retinoic acid in brain vascular development.” Journal of Neuroscience 36(29):7786-801. *Co-first authors PubMed
• Kelly, KK, MacPherson, A, Grewal, H, Strnad , Jones, J, Yu , J, Pierzchalski , K, Kane, M, Herson, P, Siegenthaler, JA (2016) “Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke.” BMC Neuroscience 17(49) DOI: 10.1186/s12868-016-0284-5. PubMed
• Wang, L., Siegenthaler, JA, Dowel, RD, Yi, R (2016) “Foxc1 reinforces quiescence in self-renewing hair follicle stem cells.” Science 351(6273): 613-7. PubMed

2014

• Arnold, TD, Niaudet, C, Pang, M, Siegenthaler, JA, Gaengel, K, Jung, B, Mukoyama, Y, Akhurst, R, Betsholtz, C, Sheppard, D, Reichardt, LF (2014) “Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αvβ8-TGFβ signaling in the brain.” Development 141(23):4489-99. PubMed
• Keeney, JG, Davis JM, Siegenthaler J, Post, MD, Nielsen, BS, Hopkins, WD and Sikela JM (2014) “DUF1220 protein domains drive proliferation in human neural stem cells and are associated with increased cortical volume in anthropoid primates.” Brain Structure and Function DOI: 10.1007/s00429-014-0814-9 PubMed

2013

• Siegenthaler, JA, Choe, Y., Patterson, K., Hsieh, I., Li, D., Jaminet, S., Daneman, R., Kume, T., Huang, E. and Pleasure, S. (2013). Foxc1 is required by pericytes during fetal brain angiogenesis. Biology Open: The Company of Biologists, 2(7):647-59. PubMed
• Siegenthaler, JA, Sohet, F and Daneman, R (2013) “Sealing off the CNS: cellular and molecular regulation of blood brain barriergenesis” Current Opinion in Neurobiology 23(6):1057-64. PubMed

University of California, San Francisco

• Zarbalis*, K, Siegenthaler*, JA, Choe, Y, May, SR, Peterson, AS, Pleasure, SJ (2007) “A novel hypomorphic Foxc1 allele with disruption of meningeal differentiation causes cortical dysplasia and skull defects.” PNAS 104:14002-14007. *Co-first authors  PubMed
• Siegenthaler, JA, Ashique, AM, ,Zarbalis, K, Patterson, KP, Hecht, JH, Kane, MA, Folias, AE, Choe, Y, May, SR, Kume, T, Napoli, JL, Peterson, AS, Pleasure, SJ (2009) “Retinoic acid from the meninges regulates cortical neuron generation.” Cell, 139:597-609. PubMed
• Hecht, JH, Siegenthaler, JA, Patterson, KP, Pleasure, SJ (2010) “Primary cellular meningeal defects cause neocortical dysplasia and dyslamination.” Annals of Neurology 68(4):454-64. PubMed
• Munji, R, Choe, Y, Li, G, Siegenthaler, JA, Pleasure, SJ (2011) “Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors.” Journal of Neuroscience 31(5): 1676-87.  PubMed
• Siegenthaler, JA and Pleasure, SJ (2011) “We have got you covered: how the meninges control brain development.” Current Opinion in Genetics and Development. 21(3): 249-55. PubMed
• Choe, Y, Siegenthaler, JA, Pleasure, SJ (2012) “A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation.” Neuron 73(4):698-712.  PubMed
• Zarbalis, C,  (2012) “Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice.” Neural Development 7:2. PubMed